24 lines
1.2 KiB
Plaintext
24 lines
1.2 KiB
Plaintext
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There has been considerable research into the synthesis of THC and its
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analogues. A prominent figure in the early work in the 40's is Roger
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Adams. Many THC analogues have been synthesized, some with potencies
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(supposedly) 512 times that of the natural THC. The two areas on the
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structure that are the pharmacological functional groups are the long
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alkyl chain on the aromatic ring and variations on the nonaromatic ring.
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Acetylation of the hydroxyl usually produces a more potent compound. Look
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in the Merck Index under Nabilone, Synhexyl, tetrahydrocannabinol,
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cannabinol, and cannabidiol. This is a good start on cannabinoid
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chemistry, but there seem to be myriad articles on nitrogen analogues of
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all sorts and other heteroatoms like sulfur. Too many for me to mention
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all of the references.
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Another author worth mentioning is T. Petrzilka (don't ask me how to
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pronounce that...). (Helv. Chim Acta 52, 1102 (1969); 50, 719 (1967);
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1416 (1967); 2111 (1967))
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St. Anthony
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--
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/ N \ O I don't need God!
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| \ | || Ph All I need is an amoeba!
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| | |_O-C-C-OH
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\ / / Ph St. Anthony | aankrom@nyx.cs.du.edu
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