22 lines
962 B
Plaintext
22 lines
962 B
Plaintext
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From Hallucinogens: Neurochemical, Behavioural, and clinical Perspecives,
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edited by B. L. Jacobs. Raven Press, New York (C) 1984
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Medicinal Chemistry and Structure Activity Relationships of Hallucinogens
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David E. Nichols and Richard A. Glennon
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Page 123-124
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The 5-hydroxy derrivative of DMT, bufotenine, or N,N-dimethyl-serotonin,
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is another naturally occuring tryptamine found to occur in South
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American Snuffs (also Bufo). Intravenours administration of of
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bufotenine was reported by Fabing and co-workers (59,60) to be
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hallucinogenic in man. THis finding is in conflict with a later
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report by Turner and Merlis (253). Apparantly, due to its low
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lipid solubility (65), bufotenine does not readily cross the
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blood-brain barrier (64,183). The initial observations made by
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Fabing et.al. (59,60) may be the result of peripheral toxic
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manifestations.
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Bufotenine has been found to be behviourally inactive,
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or only weakly active in most animals studies...
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Jeremy
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