641 lines
33 KiB
Plaintext
641 lines
33 KiB
Plaintext
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MDMA Frequently Asked Questions List
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Written By: Jon M. Taylor
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Changes since last update:
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- Inserted new credits
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- Lots of little re-wordings, tweaks and intra-document references inserted
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- Changed drug reaction section format
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- Reorganized the "how to have a good time" section a bit
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- Replaced synthesis info with the synth from _SOMM_. This is the big change
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in this revision.
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- Split one of the rumors in two
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- Fixed wrong nomenclature in analogs section
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Table of Contents:
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==================
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I. Introduction
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- Disclaimer
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- Credits
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II. Overview
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- General
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- History
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- Dosage and effects
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- Side Effects, contraindications and health information
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- How to have a good time (and not have a bad one)
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III. Chemistry
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- Structural information
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- Action mechanism
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- Synthesis
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IV. Miscellany
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- Rumor Control
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- Analogs and related compounds
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- Related Reading
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- Organizations
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===============================================================================
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I. Introduction
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===============
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Disclaimer:
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-----------
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This file is an attempt to codify the large amount of information about
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MDMA that is floating around on the net in various stages of organization into
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one easy-to-read document. It is NOT intended to be a summary of everything
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that has ever been written about MDMA, only the most (F)requently (A)sked
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(Q)uestions. If you find anything that you feel should be added, changed,
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deleted, or properly accredited, let me know.
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This FAQ list is provided for informational purposes ONLY. I do not
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advocate the use of anything described in this document, and accept NO
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responsibility for any harm that might occur as a result of acting on any of
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the information contained here. I have made every effort to ensure the
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validity of the information contained in this document, but I cannot guarantee
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100% accuracy. Read at your own risk.
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Credits:
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--------
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Many people on the net have provided much of the information that went
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into making this FAQ list. If you have contributed something to this FAQ and
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are not in the credits, please let me know.
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David Honig................................................dhonig@ics.uci.edu
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Lamont Granquist....................................lamontg@cs.washington.edu
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Chris Klausmeier..................................cklausem@jarthur.cs.hmc.edu
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Robert Jesse.............................................rjesse@us.oracle.com
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Rick Bloom..................................................................?
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Rick Doblin..................................................rickmaps@aol.com
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Peter McDermott.............................................................?
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===============================================================================
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II. Overview
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============
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General:
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--------
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MDMA (also commonly known as Ecstacy, X, E, XTC, Adam, etc.) is a drug.
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In its pure form, it is a white crystalline powder. It usually either seen in
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powder form, as pressed pills, or in capsules. Average cost ranges from $10-
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$30 (US) a hit. Common methods of ingestion are swallowing or snorting,
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although it can be smoked or injected as well. Currently, MDMA is DEA schedule
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I, and is illegal to manufacture, possess or sell in the United States. Most
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other countries have similar laws.
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History:
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--------
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MDA, an analog of MDMA (see the section on Related Compounds), was first
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synthesized in 1917 by the Merck chemical company as an appetite suppressant.
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Because of the "adverse" mental effects of the drug, it was not marketed and
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the patent expired. MDA resurfaced as a recreational drug in the late sixties,
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and in the early seventies MDMA began to appear. By the late seventies MDMA
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had dramatically increased in popularity, and by the early eighties it had come
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to the attention of the DEA. MDMA was placed in DEA schedule I in 1985. It's
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placement in schedule I was challenged in court, and the DEA lost and was
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ordered to reconsider the scheduling. They "reconsidered", and left it as
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schedule I.
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Dosage and Effects:
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-------------------
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An average dose of MDMA is around 100-150 milligrams (orally). If it is
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eaten, the effects will manifest themselves at about 45 minutes after
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ingestion; snorting, smoking or injecting it produce much more rapid effects.
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If taken orally, physical effects last about 8 hours. Mental effects last much
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longer, trailing off over a period of 1-2 days. If snorted, smoked or
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injected, the duration of the effects is reduced, but the intensity of the
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mental effects will not be much greater than if taken orally.
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The physical effects of MDMA are pretty much the same as the physical
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effects of amphetamines (that is, general potentiation of the nervous system).
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These include euphoria, hyperexcitability, extreme nervousness, accelerated
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heartbeat, sweating, dizziness, restlessness, insomnia, tooth grinding,
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incessant talking, and other effects. Paradoxically, the effects may be
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experience simultaneously with a feeling of relaxation caused by the mental
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effects.
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The mental effects are a bit more difficult to describe, since they are
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many and of widely varying effects. The major ones are:
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- Entactogenesis (meaning "touching within")
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This is a generalized feeling that all is right and good with the world.
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People on MDMA often describe feeling "at peace" or experiencing a
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generalized "happy" feeling. Also, common everyday things may seem to be
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abnormally beautiful or interesting. Alexander Shulgin reported that
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mountains that he had observed many times before appeared to be so
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beautiful that he could barely stand looking at them when he was on MDMA.
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- Empathogenesis
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Empathogenesis is a feeling of emotional closeness to others coupled with
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a breakdown of personal communication barriers. People on MDMA report
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feeling much more at ease talking to others and that any hangups that one
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may have with regard to "opening up" to others may be reduced or even
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eliminated entirely. This effect is partially responsible for MDMA being
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labeled as a "hug drug" - the increased emotional closeness makes personal
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contact very rewarding.
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Many people use MDMA primarily for this effect, reporting that it
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makes potentially awkward or uncomfortable social situations (singles
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bars, dance clubs, first dates, etc.) much more easily dealt with. "It
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[conversation] just flows like water" said one person. "It seems like you
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know exactly what to say and when to say it. It's like a filter between
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what you want to express and what comes out of your mouth that you didn't
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even know existed is stripped away." This same person also reported that
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they used to use alcohol for many of these same reasons, but found MDMA to
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be much better suited to this purpose.
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- Psychiatric effects
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Before it was made illegal, MDMA was starting to gain a reputation among
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the psychiatric community as a very useful therapeutic tool. People under
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its influence often report seeing their personal problems in a whole new
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light. "I was completely blown away the first time I did X" said the same
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person quoted above. "I saw some of my problems that I didn't even know I
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had! All of a sudden, It seemed like the source, nature and sometimes
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even the solution of all my personal difficulties were completely
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obvious." Surfacing of repressed memories has also been reported.
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- Mild visual hallucinations
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MDMA is not classified as a hallucinogen, but subtle visual distortions
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are often experienced.
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- An enhancement and distortion of the senses.
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Many strange sensory enhancements and distortions can be caused by MDMA.
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People on MDMA can experience distortions of taste, smell, and touch. It
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is possible that the mild visual distortions that MDMA causes (see above)
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may also be a function of this distortion of the senses. MDMAers can
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sometimes be seen running their hands over differently textured objects
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repeatedly, passing around scented nasal inhalers, or tasting a variety of
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foods/drinks. This effect also contributes to the "hug drug" effect
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because of the strange feeling of running one's hands over skin and
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having one's skin rubbed by someone else's hands.
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Repeated dosages of MDMA will cause the amphetamine-like affects to
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continue, but the mental effects will start to fade and can only be fully
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brought back by ceasing intake of the drug for a period of time - usually about
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a week. Also, there is a limit beyond which the mental effects will not
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increase in intensity no matter how much of the drug is taken (the "ceiling
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effect"). Thus, repeated ingestion of the drug to produce an extended period
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of euphoria is not common, and is seen primarily in conjunction with a pattern
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of methamphetamine abuse.
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Side effects, contraindications and other health information:
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-------------------------------------------------------------
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MDMA causes increases in heart rate and blood pressure in most people,
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similar to those generated by moderate exercise. Beacuse of this, people with
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a history of high blood pressure, heart trouble, stroke or hypersensitivity to
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drugs should not use MDMA, or should at the very least start with a much lower
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than average dose. People with liver problems should also be very careful when
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taking MDMA or any other drug. Also, MDMA *should not ever* be combined with
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Monoamine Oxidase Inhibitors (MAOIs). These are usually found in prescribed
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antidepressants, but if you are taking ANY prescription medication you should
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first check the label or ask a doctor or pharmacist to see if it is a MAOI
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before combining it with MDMA. Also be aware that some antidepressants (most
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notably Prozac and Zoloft) can inhibit some of the effects of MDMA.
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The euphoria that MDMA induces can make it easy to ignore bodily distress
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signals, so be very watchful for things like dehydration, muscle cramping,
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dizziness, exhaustion or overexertion. Several reports from England tell of
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all-night ravers dancing themselves into severe dehydration and heat exhaustion
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that required hospitalization.
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MDMA users also commonly report a "burnout" for one-two days afterward,
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characterized by tiredness, soreness, and dullness of the senses and mental
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processes. It is possible that this is a result of temporary depletion of
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certain neurotransmitters in the brain (see the action mechanism section
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below), and that the brain needs time to replendish them before normal mental
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prcesses are restored. Note that this does NOT mean that MDMA causes brain
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damage (see the section on rumor control).
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Combining MDMA and other recreational drugs is a popular activity. There
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are a few health risks with some of the combinations:
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- Amphetamines, Cocaine, or other stimulants:
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Since MDMA itself is an amphetamine-like stimulant, combining it with
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other stimulants can result in an increased risk of overdosage. Not
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recommended.
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- Heroin or other opiates/sedatives:
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No dangerous interactions, but the stimulant effect of the MDMA may mask
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the sedative effects of the opiate and increase the likelyhood of an
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overdosage of the opiate.
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- Alcohol:
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Alcohol can DANGEROUSLY exacerbate the dehydration that MDMA normally
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causes, as well as having the same contraindictions as listed above for heroin
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or other opiates/sedatives.
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How to have a good time (and not have a bad one):
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------------------------
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One of the basic requirements for having a good time on MDMA is to
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actually ingest real MDMA. Amphetamines, LSD, some analogs of MDMA (see the
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analogs section below), and various other drugs are sometimes passed off as
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MDMA, so be sure that you buy from someone you trust.
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Most users of MDMA report that after a cartain number of sessions (the
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number of which seems to vary from person to person), the desirable effects of
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the drug are no longer as potent. "It loses its magic" one person said. The
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exact mechanism of this effect dropoff is unknown, although it is speculated
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that the damage to serotonergic uptake neuron axons (see the rumors section)
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may have a permanent effect on the brain that renders the users less sensitive
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to MDMA.
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Because of the entactogenic effects that MDMA generates, good judgement
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may go by the wayside while tripping. In general if you expect to have to make
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a decision regarding forming, changing or terminating a relationship, engaging
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in sex, taking other drugs, or other "serious" matters, it might help to have
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someone around who is sober to help make these decisions for you.
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MDMA is used by different people for different things. Because the drug
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has such a wide range of effects, it can add to almost any activity. Here are
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some of the more common activities than people take MDMA and engage in.
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- Raves
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One of the most common setting for an MDMA trip is a rave, which is a type
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of dance club. Ravers on MDMA usually dance for long periods of time, an
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activity in which the amphetamine-like effects of MDMA play a large part.
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Raves are also a place where people who want to be around lots of others who
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are also on MDMA can go. The whole atmosphere of a Rave is conducive to
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enjoying the MDMA experience, so they can be very fun places to go. For more
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info on raves, subscribe to the newsgroup ALT.RAVE or FTP the ALT.RAVE FAQ from
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TECHNO.STANFORD.EDU in the /pub/raves directory.
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- Self-psychotherapy
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Since MDMA can catalyze a broad range of psychotherapeutic mental effects
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(surfacing of repressed memories, dealing with emotional problems, etc.),
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MDMAers sometimes will trip by themselves and spend the experience thinking
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about their problems. It has been said that "one hit of X [MDMA] is worth 3
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months of conventional psychotherapy". Whether that is an exaggeration or not,
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MDMA has been praised by many psychotherapists as a very effective means of
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dealing with personal issues. People who favor this MDMA experience often will
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want to talk to other people they are close to in order to discuss some of
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their personal issues that the MDMA has made them more aware of.
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- A replacement for amphetamines
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MDMA is also sometimes used for some of the same things that amphetamines
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are used for, typically activities that require concentration, motivation,
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creativity or energy. Doing homework, studying, playing video games, dieting,
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writing, and driving long distances are just some of the many activities that
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the stimulant effects of MDMA can make easier or more enjoyable. Warning -
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some of these activities could be hazardous. Always listen to what your body
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is telling you and use your better judgement Chronic amphetamine usage can
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result in addiction, as well as having it's own health risks.
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- The sensorium
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The sensory distortion of MDMA can make sensual activities very enjoyable.
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Touching can become such an intensely pleasurable sensation that close personal
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contact (sexual or otherwise) can be very fun, especially when coupled with
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MDMA's empathogenic effects. Hugging someone and running your hands over them
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are such a common thing to see people on MDMA doing that it is known to some as
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the 'Hug Drug'. Eating and drinking, smelling flowers and even going to the
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bathroom (!) can become very entertaining on MDMA.
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The above are just some of the many activities that can be enjoyed more
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fully while on MDMA. Use your imagination, and many others will occur to you.
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MDMA can also be mixed with other drugs for a different experience. The
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health hazards of some of these combinations were discussed in the section on
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contraindications. Here are the mental effects: (note that this is based on
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subjective information. Personal reactions may differ.)
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Drug | Information
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===============================================================================
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Marijuana | Fun, but can cloud the mental effects of the MDMA. Have to
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| smoke more before you notice it.
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--------------|----------------------------------------------------------------
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LSD or other | Can go very well together. LSD and MDMA is commonly known as
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hallucinogens | "candyflipping". Low doses of the hallucinogen are common.
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| Effects have been described as "The smoothest, most mellow trip
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| you'll ever have" and the synergy of the effects is reported to
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| be more than either alone.
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-------------------------------------------------------------------------------
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Amphetamines | You're already speeding. Why bother? Health risks noted in
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| contraindications section. NOTE: I have been told that the
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| duration of the mental effects of MDMA can be extended using
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| amphetamines after coming down off the MDMA. See the section
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| on health risks.
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--------------|----------------------------------------------------------------
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Cocaine | Same as Amphetamines. See section on health risks.
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--------------|----------------------------------------------------------------
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Heroin or | In terminal cancer patients, MDMA has been used to restore the
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other opiates | lucidity that the opiates often obscure. Other than that, no
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| information. See section on health risks.
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--------------|----------------------------------------------------------------
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Tobacco | Tastes REALLY good |->. Easy to smoke too much and not notice.
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--------------|----------------------------------------------------------------
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Alcohol | Sometimes helps if the amphetamine-like effects get too harsh.
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| Other than that, MDMA is better than alcohol for every reason
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| you'd drink (social lubricant and all that). See section on
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| health risks.
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--------------|----------------------------------------------------------------
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"Bad Trips" in the LSD sense are not common with MDMA. The trip is almost
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always pleasant and euphoric.
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In conclusion, MDMA is a drug that should not be taken lightly. The
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effects it generates are very powerful, and care should be taken at all time
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when dealing with it. Read this whole FAQ, educate yourself about the
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pleasures and pitfalls of MDMA, and be sure you are ready before you take it.
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===============================================================================
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III. Chemistry
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==============
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Structural Information
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----------------------
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MDMA is (3,4-Methylenedioxymethamphetamine). The structure of the
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molecule (insofar as it can be rendered using ASCII) is this:
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From: Chemical & Engineering News. September 9, 1985.
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"3,4-methylenedioxymethamphetamine (MDMA)....
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H H
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\ /
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C
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/ \
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O O
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\ /
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-----
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// \\
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'< >`
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\ /
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=====
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\
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/
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H C--<
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3 \
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NHCH
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3
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Action Mechanism:
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-----------------
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The action mechanism of the amphetamine-like effects is the same as for
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normal amphetamines - potentiating the central and peripheral nervous systems
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by causing an increase in the production of acetylcholine. Acetylcholine is a
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neurotransmitter responsible for propagating a signal down a nerve pathway from
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neuron to neuron. A sudden massive increase in the production of this chemical
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in the human body results in an increase in the "background noise" of the human
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nervous system.
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The action mechanism of the mental effects is throught the 5-
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hydroxytryptamine (serotonin) system in the brain. This is the same system
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that is acted upon by most psychedelic drugs. The exact effect of MDMA upon
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this system is unknown, but it is known that MDMA is taken up by the 5-HT
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uptake neurons and that this affects the action of the 5-HT system in some way.
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This system is responsible for many things in the brain, including the
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regulation of sleep patterns, mood, energy, and perception. MDMA has been
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found to cause a massive release of 5-HT in the brain, and this may be
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responsible for the changes in mood. The "ceiling" effect and the "burnout"
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effect (discussed elsewhere in this document) suggest that MDMA may cause a
|
||
|
release of all the stores of certain neurotransmitters in the brain, and that
|
||
|
the brain may need time after this massive release to replendish them.
|
||
|
|
||
|
|
||
|
Synthesis:
|
||
|
----------
|
||
|
Here is a synthesis for MDMA. It was taken from the book _Secrets of
|
||
|
Methamphetamine Manufacture_, by "Uncle Fester". This is NOT something I would
|
||
|
attempt without at least having some basic knowledge of organic chemistry.
|
||
|
Safrole, the primary precursor in this synthesis, is found naturally in oil of
|
||
|
sassafrass (about 87%), and can be extracted with simple distillation.
|
||
|
|
||
|
|
||
|
"A good alternative to the Ritter reaction is a two step procedure
|
||
|
first reacting safrole with hydrobromic acid to give 3,4-methylenedi-
|
||
|
oxyphenyl-2-bromopropane, and then taking this material and reacting
|
||
|
it with either ammonia or methylamine to yield MDA or MDMA
|
||
|
respectively. This procedure has the advantages of not being at all
|
||
|
sensitive to batch size, nor is it likely to "run away" and produce a
|
||
|
tarry mess. It shares with the Ritter reaction the advantage of using
|
||
|
cheap, simple, and easily available chemicals.
|
||
|
|
||
|
The sole disadvantage of this method is the need to do the final
|
||
|
reaction with ammonia or methylamine inside a sealed pipe. This is
|
||
|
because the reaction must be done in the temperature range of 120-
|
||
|
140 C, and the only way to reach this temperature is to seal the
|
||
|
reactants up inside of a bomb. This is not particularly dangerous, and
|
||
|
is quite safe if some simple precautions are taken.
|
||
|
|
||
|
The first stage of the conversion, the reaction with hydrobromic
|
||
|
acid, is quite simple, and produces almost a 100% yield of the bromi-
|
||
|
nated product. See the Journal of Biological Chemistry, Volume 108
|
||
|
page 619. The author is H.E. Carter. Also see Chemical Abstracts
|
||
|
1961, column 14350. The following reaction takes place:
|
||
|
|
||
|
[ Structural diagrams deleted]
|
||
|
|
||
|
To do the reaction, 200 ml of glacial acetic acid is poured into a
|
||
|
champagne bottle nestled in ice. Once the acetic acid has cooled
|
||
|
down, 300 grams (200 ml) of 48% hydrobromic acid is slowly added
|
||
|
with swirling. Once this mixture has cooled down, 100 grams of
|
||
|
safrole is slowly added with swirling. Once the safrole is added, the
|
||
|
cheap plastic stopper of the champagne bottle is wired back into
|
||
|
place, and the mixture is slowly allowed to come to room temperature
|
||
|
with occasional shaking. After about 12 hours the original two layers
|
||
|
will merge into a clear red solution. In 24 hours, the reaction is done.
|
||
|
The chemist carefully removes the stopper from the bottle, wearing
|
||
|
eye protection. Some acid mist may escape from around the stopper.
|
||
|
|
||
|
The reaction mixture is now poured onto about 500 grams of
|
||
|
crushed ice in a 1000 or 2000 ml beaker. Once the ice has melted, the
|
||
|
red layer of product is separated, and the water is extracted with about
|
||
|
l00 ml of petroleum ether or regular ethyl ether. The ether extract is
|
||
|
added to the product, and the combined product is washed first with
|
||
|
water, and then with a solution of sodium carbonate in water. The
|
||
|
purpose of these washings is to remove HBr from the product. One
|
||
|
can be sure that all the acid is removed from the product when some
|
||
|
fresh carbonate solution does not fizz in contact with the product.
|
||
|
|
||
|
Once all the acid in the product is removed, the ether must be
|
||
|
removed from it. This is important because if the ether were allowed
|
||
|
to remain in it, too much pressure would be generated in the next
|
||
|
stage inside of the bomb. Also, it would interfere with the formation
|
||
|
of a solution between the product and methylamine or ammonia. It is
|
||
|
not necessary to distill the product because with a yield of over 90%,
|
||
|
the crude product is pure enough to feed into the next stage. To
|
||
|
remove the ether from the product, the crude product is poured into a
|
||
|
flask, and a vacuum is applied to it. This causes the ether to boil off.
|
||
|
Some gentle heating with hot water is quite helpful to this process.
|
||
|
The yield of crude product is in the neighborhood of 200 grams.
|
||
|
|
||
|
With the bromo compound in hand, it is time to move onto the
|
||
|
next step which gives MDA or MDMA. See Chemical Abstracts
|
||
|
1961, column 14350. Also see Journal of the American Chemical
|
||
|
Society, Volume 68, page 1805 and Journal of the Chemistry Society,
|
||
|
part 2 1938, page 2005. The bromo compound reacts with ammonia
|
||
|
or methylamine to give MDA or MDMA:
|
||
|
|
||
|
[ Sructural diagram deleted ]
|
||
|
|
||
|
To do the reaction, 50 grams of the bromo compound is poured
|
||
|
into a beaker, and 200 ml of concentrated ammonium hydroxide (28%
|
||
|
NH3) or 40% methylamine is added. Next, isopropyl alcohol is added
|
||
|
with stirring until a nice smooth solution is formed. It is not good to
|
||
|
add too much alcohol because a more dilute solution reacts slower.
|
||
|
Now the mixture is poured into a pipe "bomb." This pipe should be
|
||
|
made of stainless steel, and have fine threads on both ends. Stainless
|
||
|
steel is preferred because the HBr given off in the reaction will rust
|
||
|
regular steel. Both ends of the pipe are securely tightened down. The
|
||
|
bottom may even be welded into place. Then the pipe is placed into
|
||
|
cooking oil heated to around 130 C. This temperature is maintained
|
||
|
for about 3 hours or so, then it is allowed to cool. Once the pipe is
|
||
|
merely warm, it is cooled down some more in ice, and the cap
|
||
|
unscrewed.
|
||
|
|
||
|
The reaction mixture is poured into a distilling flask, the glass-
|
||
|
ware rigged for simple distillation, and the isopropyl alcohol and
|
||
|
excess ammonia or methylamine is distilled off. When this is done,
|
||
|
the residue inside the flask is made acid with hydrochloric acid. If
|
||
|
indicating pH paper is available, a pH of about 3 should be aimed for.
|
||
|
This converts the MDA to the hydrochloride which is water soluble.
|
||
|
Good strong shaking of the mixture ensures that this conversion is
|
||
|
complete. The first stage of the purification is to recover unreacted
|
||
|
bromo compound. To do this, 200 to 300 ml of ether is added. After
|
||
|
some shaking, the ether layer is separated. It contains close to 20
|
||
|
grams of bromo compound which may be used again in later batches.
|
||
|
|
||
|
Now the acid solution containing the MDA is made strongly basic
|
||
|
with lye solution. The mixture is shaken for a few minutes to ensure
|
||
|
that the MDA is converted to the free base. Upon sitting for a few
|
||
|
minutes, the MDA floats on top of the water as a dark colored oily
|
||
|
layer. This layer is separated and placed into a distilling flask. Next,
|
||
|
the water layer is extracted with some toluene to get out the remaining
|
||
|
MDA free base. The toluene is combined with the free base layer, and
|
||
|
the toluene is distilled off. Then a vacuum is applied, and the mixture
|
||
|
is fractionally distilled. A good aspirator with cold water will bring
|
||
|
the MDA off at a temperature of 150 to 160 C. The free base should
|
||
|
be clear to pale yellow, and give a yield of about 20 ml. This free base
|
||
|
is made into the crystalline hydrochloride by dissolving it in ether and
|
||
|
bubbling dry HCl gas through it."
|
||
|
|
||
|
===============================================================================
|
||
|
|
||
|
IV. Miscellany
|
||
|
==============
|
||
|
|
||
|
Rumor Control
|
||
|
-------------
|
||
|
There is a lot of misinformation out there about MDMA. Here are some
|
||
|
commonly heard rumors and what the facts are about each one of them.
|
||
|
|
||
|
Rumor #1: MDMA drains your spinal fluid.
|
||
|
Untrue. A spinal tap, which lots of MDMA users who had tests run on them
|
||
|
had done to them, DOES drain the spinal fluid temporarily. The actual drug
|
||
|
itself, however, does not. Tests have revealed lowered levels of 5-HT
|
||
|
(serotonin) in the spinal fluid of people who have taken MDMA, but this is
|
||
|
related to rumor #4 (see below).
|
||
|
|
||
|
Rumor #2: MDMA ruins your back, neck, knees, or other body part.
|
||
|
Untrue. The amphetamine-like effects of MDMA, coupled with the energetic
|
||
|
dancing that many ravers take part in, may cause next-day soreness or some pain
|
||
|
in a body part. However, unless you don't take care of it this is no more
|
||
|
serious than normal back strain/sore feet/sore neck/etc.
|
||
|
|
||
|
Rumor #3: MDMA causes brain damage, parkinson's disease, etc.
|
||
|
Untrue, at least in the sense that most people view brain damage (gross
|
||
|
noticeable symptoms). There is some controversy over whether MDMA causes some
|
||
|
neuronal damage (see rumor #3), but MDMA definitely does NOT cause parkinson's
|
||
|
disease or any noticeable form of gross brain damage. This rumor got started
|
||
|
because of a mix-up by a journalist between MDMA and MPTP (1-methyl-4-phenyl-
|
||
|
1,2,3,6-tetrahydropyridine), which is a product of an error in the manufacture
|
||
|
of a synthetic opiate and has *no* relation at all to MDMA.
|
||
|
|
||
|
Rumor #4: MDMA damages the 5-HT uptake neurons in the brain.
|
||
|
The jury is still out on this one. The 5-HT (serotonin) uptake neurons
|
||
|
are the receptor sites that MDMA bonds to in the brain, and experiments done on
|
||
|
lab animals seem to suggest that MDMA may destroy 5-HT axons. However, no
|
||
|
noticeable symptoms have been observed as a result of this in either rats or
|
||
|
humans, and a common prescription weight-loss drug (fenfleuramine) produces 3
|
||
|
times the amount of the same kind of damage and has never been linked to any
|
||
|
form of brain dysfunction. If you're really paranoid, most of this "damage" may
|
||
|
be prevented by taking some Prozac or Zoloft (see the section on
|
||
|
contraindications) about 3 hours after taking the MDMA.
|
||
|
Analogues and related compounds:
|
||
|
------------------------------
|
||
|
MDMA has several chemical "cousins" and related compounds which have
|
||
|
different effects. Here are descriptions of some of the more common ones:
|
||
|
|
||
|
MDA (3,4-methylenedioxyamphetamine):
|
||
|
MDA was popular for a while during the 70s, when it was known as the 'Love
|
||
|
Drug' (a nickname sometimes associated with MDMA as well). It is similar to
|
||
|
MDMA in its effects, but is more like LSD in that it is much more mentally
|
||
|
disorienting ("stoning"). It is also supposed to be more visual as well.
|
||
|
|
||
|
MDE or MDEA (N-ethyl-methylendioxyamphetamine):
|
||
|
Commonly called "Eve" (if MDMA is "Adam", MDE is "Eve", get it?), MDE is
|
||
|
similar in its effects to MDA.
|
||
|
|
||
|
MMDA (3-methoxy-4,5-methylenedioxyamphetamine):
|
||
|
MMDA is reported to cause interesting closed-eye hallucinations, but
|
||
|
otherwise appears to be similar to MDMA.
|
||
|
|
||
|
MBDB (N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine):
|
||
|
Sometimes called "Eden". Differs structurally from MDMA only by the
|
||
|
addition of an extra carbon to the MDMA chain. Effects have been described as
|
||
|
like MDA but without an amphetamine-like effects.
|
||
|
|
||
|
GHB (Gamma-hydroxy-butyrate):
|
||
|
GHB is not chemically related to MDMA at all, but the similarity of some
|
||
|
of it's effects to those of MDMA and the similarity of the settings in which it
|
||
|
is used to those of MDMA use give it a place here.
|
||
|
GHB is a hydroxyl alcohol, and was (and still is) used by bodybuilders in
|
||
|
the same way as steroids are. Physically it is a waxy, hygroscopic solid, and
|
||
|
usually comes in small bottles about the size of hotel shampoo bottles. it is
|
||
|
usually ingested by dissolving a small amount in a glass of warm water and
|
||
|
drinking. GHB came to the attention of the MDMA crowd when it was found that it
|
||
|
produces many of the same sensory distortions that MDMA does. GHB +
|
||
|
methamphetamine is a commonly seen mixture, and supposedly produces a high that
|
||
|
is very similar to MDMA.
|
||
|
|
||
|
Related Reading:
|
||
|
----------------
|
||
|
Here are some other reading materials which can provide additional
|
||
|
information on MDMA:
|
||
|
|
||
|
PIHKAL: A chemical love story
|
||
|
Alexander and Ann Shulgin
|
||
|
1008 Pages
|
||
|
Published by Transform Press, Berkeley, California
|
||
|
The first part of this book contains autobiographical accounts of the
|
||
|
shulgins' life history and experiments with psychoactive drugs. The second
|
||
|
part describes the synthesis, dosage and effects of 179 different compounds in
|
||
|
the phenethylamine family, including MDMA and its analogs.
|
||
|
|
||
|
Ecstacy: the MDMA Story
|
||
|
Bruce Eisner
|
||
|
228 Pages
|
||
|
Published by Ronin Publishing, inc. Box 1035 Berkeley, CA 94701
|
||
|
General overview of MDMA.
|
||
|
|
||
|
E for Ecstacy
|
||
|
Nicholas Saunders
|
||
|
318 Pages
|
||
|
Published by Nicholas Saunders, 14 Neal's Yard, London WC2H 9DP England
|
||
|
Full overview of MDMA, also includes the latest version of Alexander
|
||
|
Shulgin's MDMA bibliography. Highly extensive references with summaries. This
|
||
|
book is recommended over the previous one because it is newer, larger and
|
||
|
better in general. A little chaotic in organization, though.
|
||
|
|
||
|
Through the Gateway of the Heart
|
||
|
Sophia Adamson
|
||
|
197 Pages
|
||
|
Published by Four Trees publishing, San Francisco
|
||
|
A collection of stories about drug experiences, primarily with MDMA but
|
||
|
also with Ketamine, 2C-B and other psychedelics, typically taken with MDMA.
|
||
|
|
||
|
The Healing Journey
|
||
|
Claudio Naranjo
|
||
|
Published by Random House
|
||
|
Accounts of Groundbreaking theraputic use of MDA, MMDA, Harmaline and
|
||
|
Ibogaine.
|
||
|
|
||
|
Most of these books can be ordered from various places listed in the
|
||
|
addresses FAQ, available from the ALT.DRUGS FTP archive (FTP.HMC.EDU in
|
||
|
/pub/drugs).
|
||
|
|
||
|
You can also contact MAPS (the Multidisciplinary Association for
|
||
|
Psychedelic Studies) at:
|
||
|
|
||
|
1801 Tippah Ave.
|
||
|
Charlotte NC 28205
|
||
|
|
||
|
===============================================================================
|
||
|
|