124 lines
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124 lines
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(word processor parameters LM=8, RM=78, TM=2, BM=2)
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Taken from KeelyNet BBS (214) 324-3501
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Sponsored by Vangard Sciences
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PO BOX 1031
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Mesquite, TX 75150
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October 6, 1990
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listed on KeelyNet as
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AGE2.ASC
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--------------------------------------------------------------------
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JOURNAL WATCH
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Copyright 1988 Massachusetts Medical Society. All rights
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reserved.
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Electronically reproduced at DR B'S BBS by permission from the
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publisher.
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Journal Watch, a medical literature news service, uses physician-
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editors to track important new clinical studies published in a
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core group of 20 journals. New stories are added twice a week.
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For subscription information to the print version of Journal
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Watch, call 1-800-843-6356.
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Journal Watch surveys a broad range of biomedical literature;
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it is not intended to substitute for reading the original
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publications. You should exercise individual judgment in using
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this information.
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--------------------------------------------------------------------
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9/25/90
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7. UNRAVELING THE BIOLOGY OF CELLULAR AGING
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We grow old because our cells grow old -- a process we think of as
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inevitable and immutable.
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Cancer cells, however, seem to escape the process of aging and
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become "immortal." This review of recent research sheds some light
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on the cellular aging process and suggests a connection between the
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biology of cellular aging and the biology of cancer.
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Investigators have observed that a human diploid fibroblast placed
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in a cell culture goes through a limited, predictable number of
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replications before it stops dividing.
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Moreover, the replicative life span of an animal's fibroblasts has
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been shown to correlate with the life span of the species. When a
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fibroblast becomes senescent, its growth is stopped at a particular
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part of the cell cycle (the G1/S boundary) and it ceases to respond
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to certain growth factors.
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Page 1
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Certain growth-inducing proto-oncogenes seem to be turned off, while
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concentrations of possibly growth-retarding proteins seem to be
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increased.
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Researchers speculate that cancer cells circumvent the mechanisms of
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senescence, and experiments have shown that specific molecular
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manipulations can cause a senescent cell to begin dividing again.
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It remains to be shown whether further understanding of cellular
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aging will have implications for the control of aging in plants and
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animals, but the prospect is exciting. -- ALK.
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Goldstein S.
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Replicative senescence: the human fibroblast comes of age.
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Science 1990 Sep 7; 249:1129-33
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--------------------------------------------------------------------
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If you have comments or other information relating to such topics
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as this paper covers, please upload to KeelyNet or send to the
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Vangard Sciences address as listed on the first page.
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Thank you for your consideration, interest and support.
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Jerry W. Decker.........Ron Barker...........Chuck Henderson
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Vangard Sciences/KeelyNet
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--------------------------------------------------------------------
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If we can be of service, you may contact
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Jerry at (214) 324-8741 or Ron at (214) 242-9346
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--------------------------------------------------------------------
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Page 2
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